Article
The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation.
Cell cycle (Georgetown, Tex.) - 1 Jan 2005
Ghioni Pamela, D'Alessandra Yuri, Mansueto Gelsomina, Jaffray Ellis, Hay Ronald T, La Mantia Girolama, Guerrini Luisa
Abstract excerpt
Post-translational modification of proteins by the ubiquitin-like molecule SUMO-1 regulates their stability and activity with crucial implications for many cellular processes. Here we show that p63alpha, but not p63beta and gamma, is sumoylated in vitro and in vivo at a single lysine residue, K637, in the post-SAM domain. SUMO-1 attachment targets DeltaNp63alpha for proteasome mediated degradation while it does...
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