Article
Comparative lesion sequencing provides insights into tumor evolution.
Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008
Jones Siân, Chen Wei-Dong, Parmigiani Giovanni, Diehl Frank, Beerenwinkel Niko, Antal Tibor, Traulsen Arne, Nowak Martin A, Siegel Christopher, Velculescu Victor E, Kinzler Kenneth W, Vogelstein Bert, Willis Joseph, Markowitz Sanford D
Abstract excerpt
We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes approximately 17 years for a large benign tumor to evolve into an advanced cancer but <2 years for cells...
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