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Article

Functional consequences of DNA mismatch repair missense mutations in murine models and their impact on cancer predisposition.

Biochemical Society transactions - 1 Aug 2005

Scherer S J, Avdievich E, Edelmann W

Abstract excerpt

Mutations in MMR (DNA mismatch repair) genes underlie HNPCC (hereditary non-polyposis colon cancer) and also a significant proportion of sporadic colorectal cancers. MMR maintains genome stability and suppresses tumour formation by correcting DNA replication errors and by mediating an apoptotic response to DNA damage. Analysis of mouse lines with MMR missense mutations demonstrates that these MMR functions can be...

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Identifiers

PMID: 16042575
DOI: 10.1042/BST0330689

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