Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility.

Cancer cell - 1 Aug 2004

Yang Guohze, Scherer Stefan J, Shell Scarlet S, Yang Kan, Kim Mimi, Lipkin Martin, Kucherlapati Raju, Kolodner Richard D, Edelmann Winfried

Abstract excerpt

Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer (HNPCC), and MMR defects are associated with a significant proportion of sporadic cancers. MMR maintains genome stability and suppresses tumor formation by preventing the accumulation of mutations and by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Susceptibility
Share to DNA Damage
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Screening Assays, Antitumor

Share to Fibroblasts

Share to Mutation, Missense

Share to Saccharomyces cerevisiae Proteins

Share to Survival Rate

Source

Identifiers

PMID: 15324697
DOI: 10.1016/j.ccr.2004.06.024

Genes

MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15324697-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility.PMID 15324697Read ↗

Novel dominant mutations in Saccharomyces cerevisiae MSH6.Semantic proximity Read ↗

The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis.Semantic proximity Read ↗

Functional consequences of DNA mismatch repair missense mutations in murine models and their impact on cancer predisposition.Semantic proximity Read ↗

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.Semantic proximity Read ↗

An Msh2 Point Mutation Uncouples DNA Mismatch Repair and ApoptosisSemantic proximity Read ↗

Genome-wide contributions of the MutSα- and MutSβ-dependent DNA mismatch repair pathways to the maintenance of genetic stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome.Semantic proximity Read ↗

Identification of a novel MSH6 germline variant in a family with multiple gastro-intestinal malignancies by next generation sequencing.Semantic proximity Read ↗

Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.Semantic proximity Read ↗

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function.Semantic proximity Read ↗

Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.