Article

<i>Mlh1</i> haploinsufficiency induces microsatellite instability specifically in intestine

2019-05-28

Abstract excerpt

Tumors of Lynch syndrome (LS) patients display high levels of microsatellite instability (MSI), which results from complete loss of DNA mismatch repair (MMR), in line with Knudson’s two-hit hypothesis. Why some organs, in particular those of the gastrointestinal (GI) tract, are especially prone to tumorigenesis in LS remains unknown. We hypothesized that MMR is haploinsufficient in certain tissues, compromising mi...

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Literature Corpus work: 39fb70e1-f5f6-5c28-876f-dadbe8234505
DOI: 10.1101/652198

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