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Article

Mouse models of DNA mismatch repair in cancer research.

DNA repair - 1 Feb 2016

Lee Kyeryoung, Tosti Elena, Edelmann Winfried

Abstract excerpt

Germline mutations in DNA mismatch repair (MMR) genes are the cause of hereditary non-polyposis colorectal cancer/Lynch syndrome (HNPCC/LS) one of the most common cancer predisposition syndromes, and defects in MMR are also prevalent in sporadic colorectal cancers. In the past, the generation and analysis of mouse lines with knockout mutations in all of the known MMR genes has provided insight into how loss of...

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Identifiers

PMID: 26708047
DOI: 10.1016/j.dnarep.2015.11.015
PMCID: PMC4754788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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