Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.

doi:10.1136/jmg.28.8.520

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Article

Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.

Journal of medical genetics - 1 Aug 1991

Barron L, Curtis A, Shrimpton A E, Holloway S, May H, Snell R G, Brock D J

Abstract excerpt

In a Scottish family in which Huntington's disease (HD) was segregating, recombination was observed between the D4S115/S111 and D4S43/S95 loci, with the HD gene associated with the more proximal D4S43/S95 locus. Analysis of linkage disequilibrium in Scottish families showed significant non-random...

Topics

Alleles
Chromosomes, Human, Pair 4
Female
Humans
Huntington Disease
Linkage Disequilibrium
Male
Pedigree
Recombination, Genetic
Telomere

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