Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.

doi:10.1136/jmg.30.12.1018

Back to search

Article

Significant linkage disequilibrium between the Huntington's disease locus and markers at loci D4S10, D4S95, and D4S111 in Northern Ireland.

Journal of medical genetics - 1 Dec 1993

Morrison P J, Graham C A, Nevin N C

Abstract excerpt

An analysis of the Northern Ireland Huntington's disease (HD) population of 75 families showed significant linkage disequilibrium between the HD gene and DNA markers at D4S95, D4S10, and D4S111. As the linkage disequilibrium at loci D4S10 and D4S111 is different from previous studies in the UK, b...

Topics

Alleles
Chromosomes, Human, Pair 4
Female
Gene Frequency
Genetic Markers
Genetics, Population
Haplotypes
Humans
Huntington Disease
Linkage Disequilibrium
Male
Mutation
Northern Ireland

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.