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Article

Complex patterns of linkage disequilibrium in the Huntington disease region.

American journal of human genetics - 1 Oct 1991

MacDonald M E, Lin C, Srinidhi L, Bates G, Altherr M, Whaley W L, Lehrach H, Wasmuth J, Gusella J F

Abstract excerpt

The genetic defect causing Huntington disease (HD) has been mapped to 4p16.3 by linkage analysis using DNA markers. Two apparently contradictory classes of recombination events in HD kindreds preclude precise targeting of efforts to clone the disease gene. Here, we report a new recombination even...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human, Pair 4
Female
Genetic Markers
Haplotypes
Humans
Huntington Disease
Linkage Disequilibrium
Male
Pedigree
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1680285
PMCID: PMC1683155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1680285-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Complex patterns of linkage disequilibrium in the Huntington disease region.PMID 1680285Read ↗

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A recombination event that redefines the Huntington disease region.Semantic proximity Read ↗

The Huntington's disease candidate region exhibits many different haplotypes.Semantic proximity Read ↗

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