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Article

Complex patterns of linkage disequilibrium in the Huntington disease region.

American journal of human genetics - 1 Oct 1991

MacDonald M E, Lin C, Srinidhi L, Bates G, Altherr M, Whaley W L, Lehrach H, Wasmuth J, Gusella J F

Abstract excerpt

The genetic defect causing Huntington disease (HD) has been mapped to 4p16.3 by linkage analysis using DNA markers. Two apparently contradictory classes of recombination events in HD kindreds preclude precise targeting of efforts to clone the disease gene. Here, we report a new recombination event that increases support for an internal candidate region of 2.5 Mb between D4S10 and D4S168. Analysis of 23 DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 1680285
PMCID: PMC1683155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Complex patterns of linkage disequilibrium in the Huntington disease region.PMID 1680285Read ↗

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A recombination event that redefines the Huntington disease region.Semantic proximity Read ↗

The Huntington's disease candidate region exhibits many different haplotypes.Semantic proximity Read ↗

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.Semantic proximity Read ↗

Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease.Semantic proximity Read ↗

New DNA markers in the Huntington's disease gene candidate region.Semantic proximity Read ↗

Non-random association between DNA markers and Huntington disease locus in the Italian population.Semantic proximity Read ↗

Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.Semantic proximity Read ↗

Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.Semantic proximity Read ↗

Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity.Semantic proximity Read ↗

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