Article
A linkage study with DNA markers (D4S95, D4S115, and D4S111) in Japanese Huntington disease families.
The Japanese journal of human genetics - 1 Jun 1993
Watanabe M, Kondo I, Nissato S, Wakisaka A, Toda T, Ikeda J, Wasmuth J J, Gusella J F, Kanazawa I
Abstract excerpt
Attempts to isolate the Huntington disease (HD) gene based on its position have been frustrated by apparently contradictory recombination events in HD pedigrees that have predicted two non-overlapping candidate regions: 100 kb at the telomere of the short arm of chromosome 4, and a 2.2 Mb region located internally at 4p16.3. The proximal location is also supported by the detection of a linkage disequilibrium...
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