Article
DNA analysis of distinct populations suggests multiple origins for the mutation causing Huntington disease.
Clinical genetics - 1 Jun 1993
Andrew S, Theilmann J, Almqvist E, Norremolle A, Lucotte G, Anvret M, Sorensen S A, Turpin J C, Hayden M R
Abstract excerpt
Results of association studies can be significantly biased if the ancestry of the control population is not similar to that of the affected population. One approach to overcome such a bias is to use distinct populations where controls and affected individuals are likely to be of similar descent. We have examined homogeneous populations of French, Danish and Swedish ancestry for nonrandom allelic association...
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