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Article

Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease.

Nature genetics - 1 Nov 1992

Weber B, Riess O, Wolff G, Andrew S, Collins C, Graham R, Theilmann J, Hayden M R

Abstract excerpt

No detectable rearrangements involving chromosome 4p16.3 have been observed in patients with Huntington's disease (HD). New mutations for HD could involve structural alterations which might aid the localization of the defective gene. We have reinvestigated a well documented sporadic case of HD. DNA haplotyping with markers between D4S10 and the telomeric locus D4S141 reveals a recombination event in one...

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Identifiers

PMID: 1345172
DOI: 10.1038/ng1192-216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease.PMID 1345172Read ↗

Recombination of 4p16 DNA markers in an unusual family with Huntington disease.Semantic proximity Read ↗

A recombination event that redefines the Huntington disease region.Semantic proximity Read ↗

Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3.Semantic proximity Read ↗

Complex patterns of linkage disequilibrium in the Huntington disease region.Semantic proximity Read ↗

New DNA markers in the Huntington's disease gene candidate region.Semantic proximity Read ↗

A linkage study with DNA markers (D4S95, D4S115, and D4S111) in Japanese Huntington disease families.Semantic proximity Read ↗

Molecular detection of new mutations, resolution of ambiguous results and complex genetic counseling issues in Huntington disease.Semantic proximity Read ↗

Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.Semantic proximity Read ↗

Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.Semantic proximity Read ↗

Haplotype analysis of the delta 2642 and (CAG)n polymorphisms in the Huntington's disease (HD) gene provides an explanation for an apparent 'founder' HD haplotype.Semantic proximity Read ↗

The Huntington's disease candidate region exhibits many different haplotypes.Semantic proximity Read ↗

Huntington disease in Finland: a molecular and genealogical study.Semantic proximity Read ↗

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