Article
The Huntington's disease candidate region exhibits many different haplotypes.
Nature genetics - 1 May 1992
MacDonald M E, Novelletto A, Lin C, Tagle D, Barnes G, Bates G, Taylor S, Allitto B, Altherr M, Myers R
Abstract excerpt
Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by...
Topics
- Alleles
- Base Sequence
- DNA
- Genetic Markers
- Haplotypes
- Humans
- Huntington Disease
- Molecular Sequence Data
- Restriction Mapping