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Article

Significant linkage disequilibrium between the Huntington disease gene and the loci D4S10 and D4S95 in the Dutch population.

American journal of human genetics - 1 Oct 1992

Skraastad M I, Van de Vosse E, Belfroid R, Höld K, Vegter-van der Vlis M, Sandkuijl L A, Bakker E, van Ommen G J

Abstract excerpt

Significant linkage disequilibrium has been found between the Huntington disease (HD) gene and DNA markers located around D4S95 and D4S98. The linkage-disequilibrium studies favor the proximal location of the HD gene, in contrast to the conflicting results of recombination analyses. We have analyzed 45 Dutch HD families with 19 DNA markers and have calculated the strength of linkage disequilibrium. Highly...

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PMID: 1415218
PMCID: PMC1682784

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