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Article

Recombination of 4p16 DNA markers in an unusual family with Huntington disease.

American journal of human genetics - 1 Jun 1992

Pritchard C, Zhu N, Zuo J, Bull L, Pericak-Vance M A, Vance J M, Roses A D, Milatovich A, Francke U, Cox D R

Abstract excerpt

The Huntington disease (HD) mutation has been localized to human chromosome 4p16, in a 6-Mb region between the D4S10 locus and the 4p telomere. In a report by Robbins et al., a family was identified in which an affected individual failed to inherit three alleles within the 6-Mb region originating from the parental HD chromosome. To explain these results, it was suggested that the HD locus (HD) lies close to the...

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Identifiers

PMID: 1350884
PMCID: PMC1682573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Recombination of 4p16 DNA markers in an unusual family with Huntington disease.PMID 1350884Read ↗

Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease.Semantic proximity Read ↗

Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3.Semantic proximity Read ↗

Complex patterns of linkage disequilibrium in the Huntington disease region.Semantic proximity Read ↗

A recombination event that redefines the Huntington disease region.Semantic proximity Read ↗

New DNA markers in the Huntington's disease gene candidate region.Semantic proximity Read ↗

Molecular detection of new mutations, resolution of ambiguous results and complex genetic counseling issues in Huntington disease.Semantic proximity Read ↗

Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.Semantic proximity Read ↗

A linkage study with DNA markers (D4S95, D4S115, and D4S111) in Japanese Huntington disease families.Semantic proximity Read ↗

The Huntington's disease candidate region exhibits many different haplotypes.Semantic proximity Read ↗

Linkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity.Semantic proximity Read ↗

Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.Semantic proximity Read ↗

Haplotype analysis of the delta 2642 and (CAG)n polymorphisms in the Huntington's disease (HD) gene provides an explanation for an apparent 'founder' HD haplotype.Semantic proximity Read ↗

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