Article
A recombination event that redefines the Huntington disease region.
American journal of human genetics - 1 Aug 1992
Snell R G, Thompson L M, Tagle D A, Holloway T L, Barnes G, Harley H G, Sandkuijl L A, MacDonald M E, Collins F S, Gusella J F
Abstract excerpt
We report both a recombination event that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus. We also report the cloning of other sequences in t...
Topics
- Chromosomes, Human, Pair 4
- Female
- Genetic Markers
- Genotype
- Humans
- Huntington Disease
- Linkage Disequilibrium
- Male
- Pedigree
- Polymorphism, Genetic
- Recombination, Genetic
- Restriction Mapping