Accelerating functional gene discovery in osteoarthritis.

doi:10.1038/s41467-020-20761-5

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Article

Accelerating functional gene discovery in osteoarthritis.

Nature communications - 20 Jan 2021

Butterfield Natalie C, Curry Katherine F, Steinberg Julia, Dewhurst Hannah, Komla-Ebri Davide, Mannan Naila S, Adoum Anne-Tounsia, Leitch Victoria D, Logan John G, Waung Julian A, Ghirardello Elena, Southam Lorraine, Youlten Scott E, Wilkinson J Mark, McAninch Elizabeth A, Vancollie Valerie E, Kussy Fiona, White Jacqueline K, Lelliott Christopher J, Adams David J, Jacques Richard, Bianco Antonio C, Boyde Alan, Zeggini Eleftheria, Croucher Peter I, Williams Graham R, Bassett J H Duncan

Abstract excerpt

Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic burden, yet no drugs are available that prevent disease onset or progression. Here, we develop, validate and use rapid-throughput imaging techniques to identify abnormal joint phenotypes in randomly selected mutant mice generated by the International Knockout Mouse Consortium. We identify 14 genes with functional...

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Identifiers

PMID: 33473114
DOI: 10.1038/s41467-020-20761-5
PMCID: PMC7817695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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