Article
Different contributions of the angiotensin-converting enzyme C-domain and N-domain in subjects with the angiotensin-converting enzyme II and DD genotype.
Journal of hypertension - 1 Apr 2008
van Esch Joep H M, van Gool Jeanette M G, de Bruin René J A, Payne John R, Montgomery Hugh E, Hectors Magda, Deinum Jaap, Dive Vincent, Jan Danser A H
Abstract excerpt
BACKGROUND: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism-related differences in ACE concentration do not result in differences in angiotensin levels. METHODS AND RESULTS: To investigate whether this relates to differences in the contribution of the ACE C-domain and N-domain, we quantified, using the C-domain-selective inhibitors quinaprilat and RXPA380, and the N-domain-selective...
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