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Article

An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.

PloS one - 1 Jan 2011

Danilov Sergei M, Gordon Kerry, Nesterovitch Andrew B, Lünsdorf Heinrich, Chen Zhenlong, Castellon Maricela, Popova Isolda A, Kalinin Sergey, Mendonca Emma, Petukhov Pavel A, Schwartz David E, Minshall Richard D, Sturrock Edward D

Abstract excerpt

BACKGROUND: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously, a striking familial elevation in blood ACE was explained by mutations in the ACE juxtamembrane region that enhanced...

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Identifiers

PMID: 21998728
DOI: 10.1371/journal.pone.0025952
PMCID: PMC3187827

Genes

ACE

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