Article
The angiotensin-converting enzyme gene polymorphism and responses to angiotensins and bradykinin in the human forearm.
Journal of cardiovascular pharmacology - 1 Mar 2000
van Dijk M A, Kroon I, Kamper A M, Boomsma F, Danser A H, Chang P C
Abstract excerpt
The deletion (D) allele of the angiotensin-converting enzyme (ACE) is associated with high ACE levels. Subjects homozygous for the D allele should therefore exhibit enhanced angiotensin I-induced vasoconstrictor responses and diminished bradykinin-induced vasodilator responses as compared with subjects homozygous for the insertion (I) allele. In eight II and eight DD normotensive male subjects, angiotensin I,...
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