Article
Two-stage group sequential robust tests in family-based association studies: controlling type I error.
Annals of human genetics - 1 Jul 2008
Yan Lihan K, Zheng Gang, Li Zhaohai
Abstract excerpt
In family-based association studies, an optimal test statistic with asymptotic normal distribution is available when the underlying genetic model is known (e.g., recessive, additive, multiplicative, or dominant). In practice, however, genetic models for many complex diseases are usually unknown. Using a single test statistic optimal for one genetic model may lose substantial power when the model is mis-specified....
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