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Article

A novel approach for small sample size family-based association studies: sequential tests.

European journal of human genetics : EJHG - 1 Aug 2011

Ilk Ozlem, Rajabli Farid, Dungul Dilay Ciglidag, Ozdag Hilal, Ilk Hakki Gokhan

Abstract excerpt

In this paper, we propose a sequential probability ratio test (SPRT) to overcome the problem of limited samples in studies related to complex genetic diseases. The results of this novel approach are compared with the ones obtained from the traditional transmission disequilibrium test (TDT) on simulated data. Although TDT classifies single-nucleotide polymorphisms (SNPs) to only two groups (SNPs associated with...

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Identifiers

PMID: 21427757
DOI: 10.1038/ejhg.2011.51
PMCID: PMC3172932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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