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Article

Optimal multistage designs--a general framework for efficient genome-wide association studies.

Biostatistics (Oxford, England) - 1 Apr 2009

Pahl Roman, Schäfer Helmut, Müller Hans-Helge

Abstract excerpt

Genome-wide association studies (GWAS) have become increasingly affordable but they are still costly. Therefore, cost saving 2-stage designs were proposed in the literature. The restriction to 2 stages, however, seems artificial and does not exploit the full potential of the underlying methods. We extend the 2-stage approach to the general framework of any number of stages. Based on the theory of group sequential...

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PMID: 19075295
DOI: 10.1093/biostatistics/kxn036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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