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Article

Group-combined P-values with applications to genetic association studies.

Bioinformatics (Oxford, England) - 15 Sept 2016

Hu Xiaonan, Zhang Wei, Zhang Sanguo, Ma Shuangge, Li Qizhai

Abstract excerpt

MOTIVATION: In large-scale genetic association studies with tens of hundreds of single nucleotide polymorphisms (SNPs) genotyped, the traditional statistical framework of logistic regression using maximum likelihood estimator (MLE) to infer the odds ratios of SNPs may not work appropriately. This is because a large number of odds ratios need to be estimated, and the MLEs may be not stable when some of the SNPs...

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PMID: 27259542
DOI: 10.1093/bioinformatics/btw314
PMCID: PMC5018368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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