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Article

A robust test for two-stage design in genome-wide association studies.

Biometrics - 1 Dec 2009

Kwak Minjung, Joo Jungnam, Zheng Gang

Abstract excerpt

A two-stage design is cost-effective for genome-wide association studies (GWAS) testing hundreds of thousands of single nucleotide polymorphisms (SNPs). In this design, each SNP is genotyped in stage 1 using a fraction of case-control samples. Top-ranked SNPs are selected and genotyped in stage 2 using additional samples. A joint analysis, combining statistics from both stages, is applied in the second stage....

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Source

Identifiers

PMID: 19432785
DOI: 10.1111/j.1541-0420.2008.01187.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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