Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase.

doi:10.1083/jcb.113.5.1173

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Article

Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase.

The Journal of cell biology - 1 Jun 1991

Scheibe R J, Ginty D D, Wagner J A

Abstract excerpt

Retinoic acid (RA) induced neuronal differentiation in A126-1B2 cells and 123.7 cells, two mutant lines of PC12 that are deficient in cAMP-dependent protein kinase, but not in the parental PC12 cell line. A single exposure to RA was sufficient to cause neurite formation and inhibit cell division for a period of greater than 3 wk, suggesting that RA may cause a long-term, stable change in the state of these cells....

Topics

Acetylcholinesterase
Adrenal Gland Neoplasms
Animals
Axons
Carrier Proteins
Cell Differentiation
Cell Division
Cell Line
GAP-43 Protein
Intermediate Filament Proteins
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Mutation

Nerve Growth Factors

Nerve Tissue Proteins

Neurofilament Proteins

Pheochromocytoma

Protein Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 1645738
DOI: 10.1083/jcb.113.5.1173
PMCID: PMC2289001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1645738-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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