Article
Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase.
The Journal of cell biology - 1 Jun 1991
Scheibe R J, Ginty D D, Wagner J A
Abstract excerpt
Retinoic acid (RA) induced neuronal differentiation in A126-1B2 cells and 123.7 cells, two mutant lines of PC12 that are deficient in cAMP-dependent protein kinase, but not in the parental PC12 cell line. A single exposure to RA was sufficient to cause neurite formation and inhibit cell division for a period of greater than 3 wk, suggesting that RA may cause a long-term, stable change in the state of these cells....
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