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Article

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1 Dec 1992

Abstract excerpt

Studies of adenovirus E1A oncoprotein mutants suggest that the association of E1A with the retinoblastoma protein (pRB) is necessary for E1A-mediated transformation. Mutational analysis of E1A indicates that two regions of pRB are required for E1A to form stable complexes with the retinoblastoma protein. In addition to pRB binding, these regions are necessary for E1A association with several other cellular...

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Identifiers

PMID: 1331501
DOI: 10.1128/jvi.66.12.6893-6902.1992

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Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteinsPMID 1331501Read ↗

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequencesSemantic proximity Read ↗

Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600Semantic proximity Read ↗

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Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoproteinSemantic proximity Read ↗

The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.Semantic proximity Read ↗

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor proteinSemantic proximity Read ↗

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.Semantic proximity Read ↗

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.Semantic proximity Read ↗

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1Semantic proximity Read ↗

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteinsSemantic proximity Read ↗

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other propertiesSemantic proximity Read ↗

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