Article
Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2009
Bostik Pavel, Kobkitjaroen Jaruda, Tang Weining, Villinger Francois, Pereira Lara E, Little Dawn M, Stephenson Susan T, Bouzyk Mark, Ansari Aftab A
Abstract excerpt
NK cells have been established as an important effector of innate immunity in a variety of viral infections. In HIV-1 infection in humans, alterations of NK cell function, frequency, and expression of various NK receptors have been reported to be associated with differential dynamics of disease progression. Expression of certain alleles of KIR3DL and KIR3DS receptors on NK cells was shown to correlate with levels...
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