Article
Variations in KIR genes: a study in HIV-1 serodiscordant couples.
BioMed research international - 1 Jan 2014
Chavan Vijay R, Chaudhari Deepali, Ahir Swati, Ansari Zakiya, Mehta Preeti, Mania-Pramanik Jayanti
Abstract excerpt
BACKGROUND: NK cells have anti-HIV activity mediated through killer cell immunoglobulin-like receptors (KIRs). The current prospective cohort study evaluated whether variation in KIR genes is associated with HIV infection in discordant couples (DCs), where one spouse remains seronegative (HSN) despite repeated exposure to the HIV. METHODS: KIR was genotyped using PCR SSP. Viral load and CD4 counts were estimated...
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