Article
Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2007
Pascal Véronique, Yamada Eriko, Martin Maureen P, Alter Galit, Altfeld Marcus, Metcalf Julia A, Baseler Michael W, Adelsberger Joseph W, Carrington Mary, Anderson Stephen K, McVicar Daniel W
Abstract excerpt
KIR3DL1 is a highly polymorphic killer cell Ig-like receptor gene with at least 23 alleles described, including its activating counterpart, KIR3DS1. Recently, the KIR3DS1 allele has been shown to slow progression to AIDS in individuals expressing HLA-Bw4 with isoleucine at position 80. However, due to the lack of a specific Ab, KIR3DS1 expression and function is not well characterized. In this study, we...
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