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Article

trans-dominant mutants of E1A provide genetic evidence that the zinc finger of the trans-activating domain binds a transcription factor.

Molecular and cellular biology - 1 Sept 1991

Webster L C, Ricciardi R P

Abstract excerpt

The 289R E1A protein of adenovirus stimulates transcription of early viral and certain cellular genes. trans-Activation requires residues 140 to 188, which encompass a zinc finger. Several studies have indicated that trans-activation by E1A is mediated through cellular transcription factors. In particular, the ability of the trans-dominant E1A point mutant hr5 (Ser-185 to Asn) to inhibit wild-type E1A...

Topics

Adenovirus Early Proteins
Amino Acid Sequence
Blotting, Western
Genes, Dominant
HeLa Cells
Humans
Models, Genetic
Molecular Sequence Data
Mutation
Oncogene Proteins, Viral
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trans-Activators

Zinc Fingers

Source

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Identifiers

PMID: 1831535
DOI: 10.1128/mcb.11.9.4287-4296.1991
PMCID: PMC361289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1831535-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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