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Article

Two N-terminal self-association domains are required for the dominant negative transcriptional activity of WT1 Denys-Drash mutant proteins.

Biochemical and biophysical research communications - 28 Apr 1997

Holmes G, Boterashvili S, English M, Wainwright B, Licht J, Little M

Abstract excerpt

Patients with Denys-Drash syndrome (DDS) have been shown to be constitutionally heterozygous for mutations of the WT1 gene. Almost all DDS mutations inactivate or remove the DNA-binding zinc finger region of WT1 and the resulting mutant proteins appear to act in a dominant negative manner. This may occur via WT1 self-association, which has been shown to involve the first 180 amino acids. By creating a series of...

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Source

Identifiers

PMID: 9168922
DOI: 10.1006/bbrc.1997.6545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two N-terminal self-association domains are required for the dominant negative transcriptional activity of WT1 Denys-Drash mutant proteins.PMID 9168922Read ↗

A WT1 exon 1 mutation in a child diagnosed with Denys-Drash syndrome.Semantic proximity Read ↗

Antagonism of WT1 activity by protein self-association.Semantic proximity Read ↗

WT1 mutations associated with incomplete Denys-Drash syndrome define a domain predicted to behave in a dominant-negative fashion.Semantic proximity Read ↗

Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.Semantic proximity Read ↗

Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene product.Semantic proximity Read ↗

Regulation of insulin-like growth factor I receptor promoter activity by wild-type and mutant versions of the WT1 tumor suppressor.Semantic proximity Read ↗

Novel WT1 mutation (C388Y) in a female child with Denys-Drash syndrome.Semantic proximity Read ↗

The Wilms’ Tumor Suppressor Gene (<i>wt1</i>) Product Regulates <i>Dax-1</i> Gene Expression during Gonadal DifferentiationSemantic proximity Read ↗

Denys-Drash syndrome: Relating a clinical disorder to genetic alterations in the tumor suppressor gene WT1Semantic proximity Read ↗

Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion.Semantic proximity Read ↗

DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1.Semantic proximity Read ↗

Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.Semantic proximity Read ↗

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