Article
Transcriptional activation by the papillomavirus E6 zinc finger oncoprotein.
The EMBO journal - 1 Jun 1990
Lamberti C, Morrissey L C, Grossman S R, Androphy E J
Abstract excerpt
The introduction of the bovine (BPV) or human papillomavirus E6 gene into susceptible cells can result in their transformation, but there are few clues to the mechanism of action of the E6 gene. The characteristic features of E6 proteins are their small size (approximately 150 amino acids) and the potential to form two large zinc fingers. To determine if E6 can function as a transcription factor, the BPV E6 gene...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chimera
- DNA, Viral
- DNA-Binding Proteins
- Metalloproteins
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation