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Article

In vivo mutational analysis of the NGFI-A zinc fingers.

The Journal of biological chemistry - 25 Feb 1992

Wilson T E, Day M L, Pexton T, Padgett K A, Johnston M, Milbrandt J

Abstract excerpt

NGFI-A is a mammalian transcription factor that contains zinc fingers similar to those observed in several other proteins, including NGFI-C and Krox-20. To define precisely the DNA binding domain of NGFI-A, we selected mutants using a chimeric transcriptional activator that contains the NGFI-A zinc finger domain sandwiched between the lexA DNA binding domain and the GAL4 transcriptional activating domain....

Topics

Amino Acid Sequence
Base Sequence
Chimera
DNA
DNA-Binding Proteins
Genes, Fungal
Molecular Sequence Data
Mutation
Phenotype
Plasmids
Saccharomyces cerevisiae
Sequence Alignment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trans-Activators

Transcription Factors

Zinc Fingers

Source

Identifiers

PMID: 1740423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1740423-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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