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Article

Mutant human cells with constitutive activation of NF-kappaB.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2004

Sathe Swati S, Sizemore Nywana, Li Xiaoxia, Vithalani Kalpa, Commane Mairead, Swiatkowski Shannon M, Stark George R

Abstract excerpt

We have used a genetic approach to generate eight different mutant human cell lines in which NF-kappaB is constitutively activated. These independent clones have different phenotypes and belong to several different genetic complementation groups. In one clone inhibitor of kappaB(IkappaB) kinase is constitutively active, but in the seven others it is not, despite the fact that IkappaB is degraded in all eight...

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Identifiers

PMID: 14691254
DOI: 10.1073/pnas.0306812101
PMCID: PMC314161

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Source receipt: pubmed, retrieved 7 Sept 2026.

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