Article
The DNA and Cu binding functions of ACE1 are interdigitated within a single domain.
The New biologist - 1 Jun 1990
Hu S, Fürst P, Hamer D
Abstract excerpt
We present genetic and biochemical evidence that the amino-terminal region of ACE1, the activator of yeast Cu-metallothionein gene transcription, is composed of a single domain in which the DNA- and Cu-binding residues are interdigitated. Analysis of truncation mutants showed that both the DNA an...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Carrier Proteins
- Cloning, Molecular
- Copper
- DNA
- DNA-Binding Proteins
- Metallothionein
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Saccharomyces cerevisiae Proteins
- Substrate Specificity
- Transcription Factors
- Transcription, Genetic