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Article

The DNA and Cu binding functions of ACE1 are interdigitated within a single domain.

The New biologist - 1 Jun 1990

Hu S, Fürst P, Hamer D

Abstract excerpt

We present genetic and biochemical evidence that the amino-terminal region of ACE1, the activator of yeast Cu-metallothionein gene transcription, is composed of a single domain in which the DNA- and Cu-binding residues are interdigitated. Analysis of truncation mutants showed that both the DNA and Cu interactions functions of ACE1 are contained within an amino-terminal 101 amino acid peptide that can fold into a...

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PMID: 2088504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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