Article
Mechanism of action of a dominant-negative mutant of c-Jun.
Oncogene - 1 Mar 1994
Brown P H, Chen T K, Birrer M J
Abstract excerpt
The AP-1 transcriptional activating complex, made up of Jun and Fos protein, is involved in controlling many cellular processes such as cell proliferation, differentiation and transformation. We have previously characterized a dominant-negative mutant of c-Jun called TAM-67 which forms dimers with c-Jun and c-Fos, and binds DNA as a homodimer or heterodimer with c-Jun or c-Fos. This dominant-negative mutant is a...
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