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Article

Antiviral properties of a dominant negative mutant of the herpes simplex virus type 1 regulatory protein ICP0.

The Journal of general virology - 1 Nov 1992

Weber P C, Kenny J J, Wigdahl B

Abstract excerpt

Dominant negative or trans-dominant mutants of viral proteins represent a new and exciting potential approach to antiviral therapy. Unfortunately, the extreme specificity of a given dominant negative mutant limits its general utility in treating a broad spectrum of viral diseases, since it can typically interfere with the activity of only a single viral polypeptide encoded by a single virus. However, it seems...

Topics

Antiviral Agents
Genes, Dominant
Immediate-Early Proteins
Mutation
Recombinant Proteins
Repressor Proteins
Simplexvirus
Structure-Activity Relationship
Trans-Activators
Transcription, Genetic
Ubiquitin-Protein Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Proteins

Virus Replication

Source

Identifiers

PMID: 1331297
DOI: 10.1099/0022-1317-73-11-2955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1331297-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Antiviral properties of a dominant negative mutant of the herpes simplex virus type 1 regulatory protein ICP0.PMID 1331297Read ↗

Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.Semantic proximity Read ↗

The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta.Semantic proximity Read ↗

The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated GenesSemantic proximity Read ↗

Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p.Semantic proximity Read ↗

ICP0, a regulator of herpes simplex virus during lytic and latent infectionSemantic proximity Read ↗

Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.Semantic proximity Read ↗

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Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.Semantic proximity Read ↗

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trans-dominant inhibition of herpes simplex virus transcriptional regulatory protein ICP4 by heterodimer formation.Semantic proximity Read ↗

Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes.Semantic proximity Read ↗

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