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Article

Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.

Journal of virology - 1 Jul 1992

Bentivoglio C M, Zhu J, Cole C N

Abstract excerpt

Mutations at multiple sites within the simian virus 40 (SV40) early region yield large T antigens which interfere trans dominantly with the replicative activities of wild-type T antigen. A series of experiments were conducted to study possible mechanisms of interference with SV40 DNA replication caused by these mutant T antigens. First, the levels of wild-type T antigen expression in cells cotransfected with...

Topics

3T3 Cells
Animals
Antigens, Polyomavirus Transforming
Base Sequence
Cell Line
DNA Replication
DNA, Viral
Genes, Dominant
Mice
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simian virus 40

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Identifiers

PMID: 1318402
DOI: 10.1128/JVI.66.7.4209-4219.1992
PMCID: PMC241224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1318402-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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