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Article

Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.

Journal of virology - 1 Jul 1992

Bentivoglio C M, Zhu J, Cole C N

Abstract excerpt

Mutations at multiple sites within the simian virus 40 (SV40) early region yield large T antigens which interfere trans dominantly with the replicative activities of wild-type T antigen. A series of experiments were conducted to study possible mechanisms of interference with SV40 DNA replication caused by these mutant T antigens. First, the levels of wild-type T antigen expression in cells cotransfected with...

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Identifiers

PMID: 1318402
DOI: 10.1128/JVI.66.7.4209-4219.1992
PMCID: PMC241224

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