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Article

Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast.

RNA (New York, N.Y.) - 1 Apr 2008

Gustavsson Marie, Ronne Hans

Abstract excerpt

We have screened a collection of haploid yeast knockout strains for increased sensitivity to 5-fluorouracil (5-FU). A total of 138 5-FU sensitive strains were found. Mutants affecting rRNA and tRNA maturation were particularly sensitive to 5-FU, with the tRNA methylation mutant trm10 being the most sensitive mutant. This is intriguing since trm10, like many other tRNA modification mutants, lacks a phenotype under...

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Source

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Identifiers

PMID: 18314501
DOI: 10.1261/rna.966208
PMCID: PMC2271368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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