Article
Associations between the functional polymorphisms in the ABCB1 transporter gene and colorectal cancer risk: a case-control study in Turkish population.
Toxicology mechanisms and methods - 1 May 2013
Özhan Gül, Kara Mehtap, Sari Fatih M, Yanar Hakan T, Ercan Gulcin, Alpertunga Buket
Abstract excerpt
Colorectal cancer is among the most common cancer types in the world and its etiology involves the interaction of genetic and environmental factors. ABCB1 is highly expressed in the apical surface of colonic epithelial cells and acts as an efflux pump by transporting toxic endogenous substances, drugs and xenobiotics out of cells. ABCB1 polymorphisms may either change its protein expression or alter its function....
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