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Evaluating linkage disequilibrium and recombination provides a haplotype-tagging SNP panel of the major histocompatibility complex in African Americans.

Genes and immunity - 1 Apr 2008

Kelley J M, Hughes L B, Feng R, Liu N, Padilla M A, Vaughan L K, Bridges S L

Abstract excerpt

The major histocompatibility complex (MHC) (Chromosome 6p21.3) is a dynamic, immune gene-rich region that is associated with multiple diseases. Haplotype-tagging single-nucleotide polymorphism (htSNP) panels for the MHC can aid association studies but have only been reported for African, Asian and Caucasian populations to date. We genotyped 2154 SNPs spanning a 3.8-Mb region of the classical MHC in 94 healthy...

Topics

Black or African American
Gene Frequency
Haplotypes
Humans
Linkage Disequilibrium
Major Histocompatibility Complex
Polymorphism, Single Nucleotide
Recombination, Genetic
United States

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18305489
DOI: 10.1038/gene.2008.6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18305489-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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