Article
Patterns of linkage disequilibrium in the MHC region on human chromosome 6p.
Human genetics - 1 Mar 2004
Stenzel Annette, Lu Timothy, Koch W Andreas, Hampe Jochen, Guenther Simone M, De La Vega Francisco M, Krawczak Michael, Schreiber Stefan
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in the human genome are thought to be organised into blocks of high internal linkage disequilibrium (LD), separated by intermittent recombination hotspots. Since understanding haplotype structure is critical for an accurate assessment of inter-individual genetic differences, we investigated up to 968 SNPs from a 10-Mb region on chromosome 6p21, including the human major...
Topics
- Black or African American
- Chromosomes, Human, Pair 6
- Genetics, Population
- Germany
- Humans
- Linkage Disequilibrium
- Major Histocompatibility Complex
- Norway
- Polymorphism, Single Nucleotide
- Recombination, Genetic