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Article

Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Feb 2008

Schmidt Eric F, Shim Sang-Ohk, Strittmatter Stephen M

Abstract excerpt

Semaphorin activation of Plexin (Plex) receptors provides axonal guidance during neuronal development. Two families of cytoplasmic proteins, collapsin response mediator proteins (CRMPs) and molecules interacting with CasL (MICALs), have been implicated in Plexin function. The relationship between CRMP and MICAL signaling has not been defined nor is the mechanism by which Plexin activates MICAL clear. Here, we...

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Identifiers

PMID: 18305261
DOI: 10.1523/JNEUROSCI.5646-07.2008
PMCID: PMC2846290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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