Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.

Cell - 28 Jun 2002

Terman Jonathan R, Mao Tianyi, Pasterkamp R Jeroen, Yu Hung-Hsiang, Kolodkin Alex L

Abstract excerpt

Members of the semaphorin family of secreted and transmembrane proteins utilize plexins as neuronal receptors to signal repulsive axon guidance. It remains unknown how plexin proteins are directly linked to the regulation of cytoskeletal dynamics. Here, we show that Drosophila MICAL, a large, multidomain, cytosolic protein expressed in axons, interacts with the neuronal plexin A (PlexA) receptor and is required...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Cell Adhesion Molecules, Neuronal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoskeleton

Share to Flavin-Adenine Dinucleotide

Share to Flavoproteins

Share to LIM Domain Proteins

Share to Mixed Function Oxygenases

Share to Semaphorins

Source

Identifiers

PMID: 12110185
DOI: 10.1016/s0092-8674(02)00794-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.PMID 12110185Read ↗

Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases.Semantic proximity Read ↗

Drosophila Plexin B is a Sema-2a receptor required for axon guidance.Semantic proximity Read ↗

Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein.Semantic proximity Read ↗

Plexin A is a neuronal semaphorin receptor that controls axon guidance.Semantic proximity Read ↗

MICAL1 activation by PAK1 mediates actin filament disassemblySemantic proximity Read ↗

The extracellular matrix proteoglycan perlecan facilitates transmembrane semaphorin-mediated repulsive guidance.Semantic proximity Read ↗

Prevalence and functional roles of intrinsic disorder in the [F-actin]-monooxygenase MICAL family members and their interactorsSemantic proximity Read ↗

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments.Semantic proximity Read ↗

Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.Semantic proximity Read ↗

The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance.Semantic proximity Read ↗

Biochemical function of the LCA linked protein, aryl hydrocarbon receptor interacting protein like-1 (AIPL1). Role of AIPL1 in retina.Semantic proximity Read ↗

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.