Article
The semaphorin 3A receptor may directly regulate the activity of small GTPases.
FEBS letters - 1 Dec 2000
Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel A W
Abstract excerpt
The axon guidance signal semaphorin 3A induces the rapid collapse of growth cones by activating a receptor complex that contains neuropilin-1 as the ligand-binding and a plexin as the signal-transducing subunit. Here we show that plexins bind Rho-like GTPases and may directly regulate their activity. The cytoplasmic domain of plexins shows sequence similarity to GTPase activating proteins (GAPs) and mutation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.