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Article

Identification of an Evolutionarily Conserved Heterotrimeric Protein Complex Involved in Protein Targeting

1 Nov 1998

Abstract excerpt

In Caenorhabditis elegans, lin-2, lin-7, and lin-10 genetically interact to control the trafficking of the Let-23 growth factor receptor to the basolateral surface of body epithelia. The human homologue of the lin-10 gene has recently been identified as a member of the X11 gene family. The X11 proteins contain one phosphotyrosine binding (PTB) and two PSD-95.Dlg.ZO-1 (PDZ) domains as well as an extended amino...

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PMID: 9822620
DOI: 10.1074/jbc.273.48.31633

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