Article
PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments.
Nature neuroscience - 1 Jan 2015
Delloye-Bourgeois Céline, Jacquier Arnaud, Charoy Camille, Reynaud Florie, Nawabi Homaira, Thoinet Karine, Kindbeiter Karine, Yoshida Yutaka, Zagar Yvrick, Kong Youxin, Jones Yvonne E, Falk Julien, Chédotal Alain, Castellani Valérie
Abstract excerpt
Robo-Slit and Plexin-Semaphorin signaling participate in various developmental and pathogenic processes. During commissural axon guidance in the spinal cord, chemorepulsion by Semaphorin3B and Slits controls midline crossing. Slit processing generates an N-terminal fragment (SlitN) that binds to Robo1 and Robo2 receptors and mediates Slit repulsive activity, as well as a C-terminal fragment (SlitC) with an...
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