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Article

Intragenic suppression of a deletion mutation of the nonstructural gene of an influenza A virus.

Journal of virology - 1 Aug 1991

Treanor J J, Buja R, Murphy B R

Abstract excerpt

The influenza A/Alaska/77 (H3N2) virus mutant 143-1 is temperature sensitive (ts) due to a spontaneous in-frame 36-nucleotide deletion in the nonstructural (NS) gene segment, which leads to a 12-amino-acid deletion in the NS1 protein. In addition, it has a small-plaque phenotype on MDCK cell monolayers. However, phenotypically revertant (i.e., ts+) viruses were isolated readily following replication of the 143-1...

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Identifiers

PMID: 1830112
DOI: 10.1128/JVI.65.8.4204-4210.1991
PMCID: PMC248856

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