Article
Intragenic suppression of a deletion mutation of the nonstructural gene of an influenza A virus.
Journal of virology - 1 Aug 1991
Treanor J J, Buja R, Murphy B R
Abstract excerpt
The influenza A/Alaska/77 (H3N2) virus mutant 143-1 is temperature sensitive (ts) due to a spontaneous in-frame 36-nucleotide deletion in the nonstructural (NS) gene segment, which leads to a 12-amino-acid deletion in the NS1 protein. In addition, it has a small-plaque phenotype on MDCK cell mono...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Capsid
- Cell Line
- Cricetinae
- DNA, Viral
- Influenza A virus
- Molecular Sequence Data
- Mutation
- Pan troglodytes
- Polymerase Chain Reaction
- Protein Conformation
- Serial Passage
- Suppression, Genetic
- Viral Core Proteins
- Viral Nonstructural Proteins
- Virus Replication