Article
Analysis of influenza A virus temperature-sensitive mutants with mutations in RNA segment 8.
The Journal of general virology - 1 Jun 1990
Hatada E, Hasegawa M, Shimizu K, Hatanaka M, Fukuda R
Abstract excerpt
Temperature-sensitive (ts) mutants of influenza virus strain A/Udorn/72 (H3N2 subtype) with lesions in RNA segment 8 exhibited intrasegmental complementation, and were divided in two complementation groups (H1 and H2) on MDCK cells. The nucleotide sequence of segment 8 was determined for three of these mutants. The H1 strains, ICR1629 and SPC45, have a single amino acid substitution in the coding region of the...
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